4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

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Chemical Name:4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide
CAS No.:1415036-46-2
Molecular Formula:C₁₇H₁₇Br₂N₃O₄S
Molecular Weight:519.214
Hs Code.:

Synonyms:4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

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Chemical Property of 4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

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Technology Process of 4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

There total 4 articles about 4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1415036-38-2
4,5-dibromo-1-methyl-1H-pyrrole-2-carbohydrazide

: 107-96-0
3-mercaptopropionic acid

: 1415036-46-2
4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.09.073

Reference yield:

: 120309-50-4
2,2,2-trichloro-1-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)ethanone

: 1415036-46-2
4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2012.09.073

Reference yield:

: 21898-65-7
1-methyl-2-trichloroacetyl-1H-pyrrole

: 1415036-46-2
4,5-dibromo-N-(2-(2-hydroxy-4-methoxyphenyl)-4-oxo-1,3-thiazinan-3-yl)-1-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / chloroform / 2 h / 0 - 5 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With bromine; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2012.09.073