107-96-0Relevant articles and documents
Reduction Potentials and Exchange Reactions of Thiyl Radicals and Disulfide Anion Radicals
Surdhar, Parminder S.,Armstrong, David A.
, p. 6532 - 6537 (1987)
Redox equilibria between RS. and -S-S-- radicals, and between these types of radical and phenoxyl and chlorpromazine (ClPz.2+) radicals, have been investigated in aqueous solutions at pHs over the range 6-10 to obtain a self-consistent set of redox potentials for the reactions PhO. + H+ + e- = PhOH (4), RSS.R + 2H+ + e- = 2RSH (11), and RS. + H+ + e- = RSH (18), in sulfur systems with alkyl R groups.Absolute standard potentials were calculated on the of E0 = 0.83 V for the chlorpromazine couple.The results for E04 (=1.35 +/- 0.02 V) and E018 (=1.33 +/- 0.02 V) were in agreement with values calculated from thermodynamic data within the known uncertainties.E018 was found to exhibit a falloff when electron-rich groups, such as the two methyls of penicillamine or the CO2- of β-mercaptoacetic acid, were present on the carbon adjacent to the S atom.However, the effect was relatively small (ca. 10-14 mV).E011 was 1.72 +/- 0.02 V for β-mercaptoethanol.The corresponding potentials for the cyclic anions of dithiothreitol, dithioerythritol, and lipoamide were the same within experimental error, but the uncertainties were larger (+/- 0.04 V).For the reaction e- + -S-S- = -S-S-- (22), the magnitude of E022 was calculated to be -1.60 V, showing that only strongly reducing species could donate electrons to disulfide.Rate constants for several of the forward and backward reactions in the equilibria were also determined.
Green method for synthesizing high value-added mercaptoacid by catalyzing addition reaction of H2S and olefine acid by using ionic liquid as catalyst
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Paragraph 0041; 0049-0050; 0053-0054, (2021/05/05)
The invention relates to a green method integrating catalysis, reaction and separation, which is used for producing beta-mercapto carboxylic acid through addition of alpha, beta-unsaturated carboxylic acid and H2S by taking amino-functionalized hydrophobic ionic liquid as a catalyst. H2S is activated through tertiary amine alkaline sites contained in the ionic liquid, so that H2S and double bonds of alpha, beta-unsaturated carboxylic acid are subjected to an addition reaction, and recycling of H2S is realized. The product obtained after the reaction can be subjected to water phase liquid-liquid extraction to realize separation of the catalyst and the product, and the ionic liquid can be recycled. In the system, the ionic liquid is both a catalytic medium and a reaction medium, no other organic solvent participates in the system, H2S is efficiently utilized, meanwhile, high-added-value products such as mercapto acid are obtained, and the method is more economical and environmentally friendly and conforms to the development concept of green chemical industry.
Method for synthesizing 3-mercaptopropionic acid from acidic waste gas
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Paragraph 0027; 0031-0035; 0037; 0041-0047; 0051-0055; 0057, (2020/05/01)
The invention relates to the technical field of sulfhydryl compound synthesis, and in particular, relates to a method for synthesizing 3-mercaptopropionic acid from acid waste gas. The method comprises the steps: firstly, purifying hydrogen sulfide in the acidic waste gas by a pressure swing adsorption method; secondly, synthesizing 3-mercaptopropionic acid: step 1, selecting materials; step 2, carrying out a first-step reaction; step 3, carrying out a second-step reaction; and step 4, carrying out a third-step reaction. According to the method for synthesizing the 3-mercaptopropionic acid from the acid waste gas, hydrogen sulfide in the acid waste gas discharged from an oil refinery is adopted, waste is turned into wealth, reasonable utilization of resources is taken as guidance, and the3-mercaptopropionic acid is synthesized with a low-cost and less-'three wastes' method. According to the method, acrylic acid and the hydrogen sulfide product obtained in the first step are used as raw materials, triethylamine is used as a catalyst, and dimethylacetamide is used as a solvent, so that the reaction conversion rate is high, the yield is high, byproducts are reduced, the traditional process route is broken through, the problem of three wastes caused by acidification and extraction is avoided, and the method is an excellent synthesis and post-treatment route.
Method for preparing mercaptocarboxylic acid or derivatives thereof by aminolysis of thioureidocarboxylic acid or derivatives thereof
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Paragraph 0008, (2020/06/09)
The invention relates to a method for preparing mercaptocarboxylic acid or derivatives thereof by aminolysis of thioureidocarboxylic acid or derivatives thereof. The method mainly comprises the following steps: 1, dissolving thioureidocarboxylic acid or a derivative thereof in ammonia water or a mixed solution of ammonia water and a cosolvent, heating the system to 40-150 DEG C, and reacting for long time until reaction of the thioureido salt is finished; 2, cooling the reaction system, neutralizing the reaction system by using acid, removing the solvent by using a solvent extraction system, and separating to obtain the mercaptocarboxylic acid or the derivative thereof; and 3, concentrating and filtering the residual water phase or organic phase, recycling the distilled water phase or organic phase, and taking the solid ammonium salt mixture as a nitrogen fertilizer. According to the method, the defects that pollutants are complex and difficult to treat, and the environment is pollutedin the prior art that metal ions such as NaOH are adopted for alkaline hydrolysis of thioureidocarboxylic acid and derivatives thereof to prepare mercaptocarboxylic acid and derivatives thereof are overcome. The method has the advantages of simple process, low cost, no environmental pollution and the like, and can basically realize zero emission of three wastes.
Preparation method of 3-mercaptopropionic acid
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Paragraph 0053-0064, (2019/11/13)
The embodiment of the invention relates to the field of synthesis of sulfhydryl compounds, in particular to a preparation method of 3-mercaptopropionic acid. The preparation method includes the stepsthat sodium acrylate and sodium bisulfide or sodium sulfide are mixed and have a reaction; the sodium sulfide is added (or the sodium sulfide and powdered sulfur are added), and the reaction is continued; crystallization and acidification by adding acid are conducted, and a 3-mercaptopropionic acid solution is obtained. According to the preparation method, the costs of raw materials are low, the yield of the 3-mercaptopropionic is high, the purity of the 3-mercaptopropionic is high, solid waste and a solvent can be separated and recycled, a sodium salt is used as an industrial product after crystallization, the solvent is distilled, recycled and reused, and three wastes are easy to process.
Thiourea derivative and thiohydracrylic acid parallel production method
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Paragraph 0053; 0054, (2019/03/25)
The invention belongs to the technical field of organic synthesis and particularly discloses a thiourea derivative and thiohydracrylic acid parallel production method. The thiourea derivative and thiohydracrylic acid parallel production method comprises neutralizing and aminolyzing S-acrylic-dithiocarbamate in aqueous or organic solvent to obtain thiourea derivatives and the by-product of 3-mercapto propionate, wherein the 3-mercapto propionate is acidized into 3-mercapto propionic acid. The thiourea derivative and thiohydracrylic acid parallel production method provides a practical method forsynthesis of the thiourea derivatives and the 3-mercapto propionic acid and has the advantages of being mild in reaction, short in reaction time, simple in technical process and high in yield of thethiourea derivatives and the 3-mercapto propionic acid, thereby achieving certain industrial economic values.
Preparation method of beta-sulfhydryl carboxylic acid compound
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Paragraph 0068; 0073; 0074; 0080; 0082, (2018/06/26)
The invention provides a preparation method of a beta-sulfhydryl carboxylic acid compound. A solid base catalyst used in the method has suitable alkali strength, so that not only is hydrogen sulfide enabled to be activated and a reaction promoted to be carried out, but the binding between carboxyl groups and active sites in raw materials or products is also inhibited, and the active sites are prevented from being deactivated slowly. Furthermore, the solid base catalyst selects a polyhydroxy compound as a carrier, and a great deal of hydroxyl groups on the surface of the carrier can promote thehydrogen sulfide to be dissolved in a reaction system and adsorbed on the surface of the catalyst so as to enable the hydrogen sulfide to be migrated to the positions around the active sites for being activated, so that the high conversion rate and high selectivity of the reaction also can be enabled to be reached at the lower pressure, and the catalytic stability is better. In addition, the preparation method is mild in reaction conditions, and the gas-liquid phase reaction is carried out under the conditions of low temperature and low pressure, so that the method is easily applied to industry. Experiments prove that the reaction conversion rate and selectivity of the beta-sulfhydryl carboxylic acid compound prepared by the method are respectively not less than 98% and 88%. After the compound is continuously evaluated for 100h, the catalytic stability of the compound is proved to be better.
METHOD FOR PRODUCING 3-MERCAPTOPROPIONIC ACID, AND METHODS USING SAME FOR PRODUCING CARBOXYLIC ACID ESTER COMPOUND HAVING MERCAPTO GROUP AND THIOURETHANE-BASED OPTICAL MATERIAL
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Paragraph 0053; 0054, (2018/07/15)
A method for producing 3-mercaptopropionic acid and methods using same for producing a carbonic acid ester compound having a mercapto group and a thiourethane-based optical material. The present invention improves a process during the production of 3-mercaptopropionic acid, significantly increases yield, and reduces the temperature and time during vacuum distillation, thereby preventing the destruction of a product and significantly increasing productivity. The present invention allows high-purity 3-mercaptopropionic acid having an excellent color to be finally yielded; accordingly, by using same, a high-purity carbonic acid ester compound having an excellent color and a mercapto group can be inexpensively obtained. A thiourethane-based polymeric composition and a thiourethane-based optical material obtained by polymerizing same can likewise be inexpensively obtained by using said carbonic acid ester compound. Such carbonic acid ester compound can be used for the production of inexpensive thiourethane optical lenses; consequently, inexpensive optical lenses having an excellent color can be obtained.
Microchannel reactor-based cyano hydrolysis reaction method
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Paragraph 0049-0058, (2018/08/04)
The invention discloses a microchannel reactor-based cyano compound hydrolysis reaction method, and particularly, a compound comprising a cyano group in the molecule has the cyano hydrolysis reactionby using a microchannel reactor under the action of alkaline or acid-alkaline substances. By using the microchannel reactor in the process, the raw material is instantaneously evenly mixed and efficiently transfers heat; the most important danger of rushing of the material in the production process, caused by hydrolysis of the cyano compound through the alkali, is avoided; meanwhile, the equivalence ratio of the raw material in the reaction process is also reduced; the side reaction is reduced; the reaction time is shortened to dozens of minutes or even dozens of seconds. In a word, the process improves the operation safety of the reaction, the safe enlarged production of the cyano compound is realized, the time for the hydrolysis reaction of the cyano compound is shortened, the reaction selectivity and the reaction efficiency are improved, the energy consumption of the production is reduced, the use ratio of the raw material is increased, the production process is more environmentallyfriendly, the production cost is low, meanwhile, the used equipment occupies a small area, the production capacity of the equipment is high, and the production efficiency and the production capacityare greatly improved.
Preparation method of sulfhydryl compound
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Paragraph 0029; 0030; 0031; 0032; 0035; 0036; 0039; 0040, (2017/08/27)
The invention belongs to the technical field of preparation of sulfur-containing compounds, and relates to a preparation method of a sulfhydryl compound. The sulfhydryl compound is prepared through taking an acrylic acid type compound as a raw material and taking a high-polarity compound as a solvent and introducing H2S gas to react under normal pressure in the presence of a catalyst and an auxiliary agent. The preparation method of the sulfhydryl compound has the advantages of moderate reaction conditions, rapid reaction speed, high conversion ratio and high selectivity, and industrial application is easy to realize.
