ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Base Information

Chemical Name:ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
CAS No.:1063714-35-1
Molecular Formula:C₂₂H₂₃NO₇
Molecular Weight:413.427
Hs Code.:

Synonyms:ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

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Chemical Property of ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

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Technology Process of ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

There total 5 articles about ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1063714-11-3,1318166-34-5,1318166-37-8
ethyl 2-amino-6-(3',5'-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

: 1063714-35-1
ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

: 1063714-33-9
ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-(3'-hydroxy-5'-methoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 0 ℃; Molecular sieve;
DOI:10.1021/jm9005059

Reference yield:

: (3,5-dihydroxyphenyl)boronic acid

: 1063714-35-1
ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 24 h / 20 °C / Inert atmosphere

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: Heating

2.3: 0.5 h / Heating

3.1: ethanol; sodium / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With ethanol; palladium diacetate; sodium; potassium carbonate; triphenylphosphine; trichlorophosphate; In 1,2-dimethoxyethane; water;
DOI:10.1021/jm200764t

Reference yield:

: 64-17-5
ethanol

: 1318166-14-1
C₁₅H₁₀O₄

: 105-56-6
ethyl 2-cyanoacetate

: 1063714-35-1
ethyl 2-amino-6-(3',5'-dihydroxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Guidance literature:: ethyl 2-cyanoacetate; With ethanol; sodium; at 20 ℃; for 0.5h; Inert atmosphere;

ethanol; C₁₅H₁₀O₄; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200764t