2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

Base Information

Chemical Name:2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid
CAS No.:847671-53-8
Molecular Formula:C₂₂H₁₉N₅O₈
Molecular Weight:481.422
Hs Code.:

Synonyms:2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

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Chemical Property of 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

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Technology Process of 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

There total 9 articles about 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 847671-52-7
ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

: 847671-53-8
2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

Guidance literature:: With sodium hydroxide; acetic acid; In ethanol; water; at 4 ℃;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 154365-36-3
3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester

: 847671-53-8
2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / KF / dimethylformamide / 20 - 60 °C

2: 94 percent / NaOH; HCl / dioxane; H₂O / 24 h / 20 °C

3: 73 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

4: 98 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

5: 76 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

6: 70 percent / hydroxylammonium chloride; triethylamine / ethanol / 50 °C

7: 57 percent / pyridine / 6 h / 120 °C

8: 99 percent / NaOH; acetic acid / ethanol; H₂O / 4 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; potassium fluoride; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 386214-81-9
2,4-dimethyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

: 847671-53-8
2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

2: 98 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

3: 76 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

4: 70 percent / hydroxylammonium chloride; triethylamine / ethanol / 50 °C

5: 57 percent / pyridine / 6 h / 120 °C

6: 99 percent / NaOH; acetic acid / ethanol; H₂O / 4 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004