ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

Base Information

Chemical Name:ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate
CAS No.:847671-52-7
Molecular Formula:C₂₄H₂₃N₅O₈
Molecular Weight:509.475
Hs Code.:

Synonyms:ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

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Chemical Property of ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

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Technology Process of ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

There total 8 articles about ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 541-41-3
chloroformic acid ethyl ester

: 847671-51-6
ethyl 2-({[7-({4-[amino(hydroxyimino)methyl]benzoyl}amino)-2,4-dimethyl-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

: 847671-52-7
ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

Guidance literature:: With pyridine; at 120 ℃; for 6h;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 154365-36-3
3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester

: 847671-52-7
ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / KF / dimethylformamide / 20 - 60 °C

2: 94 percent / NaOH; HCl / dioxane; H₂O / 24 h / 20 °C

3: 73 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

4: 98 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

5: 76 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

6: 70 percent / hydroxylammonium chloride; triethylamine / ethanol / 50 °C

7: 57 percent / pyridine / 6 h / 120 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; potassium fluoride; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004

Reference yield:

: 386214-81-9
2,4-dimethyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

: 847671-52-7
ethyl 2-{[(2,4-dimethyl-7{[4-(5oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoyl]amino}-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate; N-methylmorpholine / dimethylformamide / -10 - 20 °C / pH 8

2: 98 percent / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

3: 76 percent / triethylamine / CH₂Cl₂ / 6 h / -10 - 20 °C

4: 70 percent / hydroxylammonium chloride; triethylamine / ethanol / 50 °C

5: 57 percent / pyridine / 6 h / 120 °C

With 4-methyl-morpholine; pyridine; hydroxylamine hydrochloride; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.09.004