1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Base Information

Chemical Name:1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride
CAS No.:1380315-98-9
Molecular Formula:C₂₆H₃₇N₇O₄*ClH
Molecular Weight:548.085
Hs Code.:

1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Synonyms:1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Suppliers and Price of 1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

There total 10 articles about 1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1380315-97-8
1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea

: 1380315-98-9
1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water;

Reference yield:

: 16754-80-6
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 1380315-98-9
1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 - 110 °C

2: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C

4: thiophenol; caesium carbonate / acetonitrile / 22 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 16.5 h / 65 °C

6: trifluoroacetic acid; water / 5.5 h / 0 - 20 °C

7: hydrogenchloride / water; methanol

With hydrogenchloride; (1S)-10-camphorsulfonic acid; water; tetra-(n-butyl)ammonium iodide; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; acetone; acetonitrile; butan-1-ol;

Reference yield:

: 1380315-92-3
(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

: 1380315-98-9
1-(4-(tert-butyl)phenyl)-3-(3-((((2R,3S,4R,5R)-5-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C

3: thiophenol; caesium carbonate / acetonitrile / 22 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 16.5 h / 65 °C

5: trifluoroacetic acid; water / 5.5 h / 0 - 20 °C

6: hydrogenchloride / water; methanol

With hydrogenchloride; (1S)-10-camphorsulfonic acid; water; tetra-(n-butyl)ammonium iodide; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; acetone; acetonitrile;