(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Base Information

Chemical Name:(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS No.:1380315-92-3
Molecular Formula:C₂₀H₂₄N₄O₆
Molecular Weight:416.434
Hs Code.:

Synonyms:(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

There total 1 articles about (2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 20781-20-8
2,4-Dimethoxybenzylamine

: 16754-80-6
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 1380315-92-3
(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 100 - 110 ℃; for 20h;

Reference yield:

: 1380315-92-3
(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

: 1380316-08-4
5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

2.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: trimethylphosphane / tetrahydrofuran / 20 h / 20 °C

3.2: 2 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / propiononitrile / 68 h / 95 °C

6.1: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 1 h / 85 °C

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; (1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetone; propiononitrile;

Reference yield:

: 1380315-92-3
(2R,3R,4S,5R)-2-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

: 1380316-09-5
N-(2-amino-4-(tert-butyl)phenyl)-5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

2.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: trimethylphosphane / tetrahydrofuran / 20 h / 20 °C

3.2: 2 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / propiononitrile / 68 h / 95 °C

6.1: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 1 h / 85 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 19 h / 20 °C

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; (1S)-10-camphorsulfonic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; propiononitrile;