1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

Base Information

Chemical Name:1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline
CAS No.:871834-54-7
Molecular Formula:C₂₀H₁₇F₉N₂
Molecular Weight:456.354
Hs Code.:

Synonyms:1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

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Technology Process of 1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

There total 5 articles about 1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 871834-53-6
2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 871834-54-7
1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 - 80 ℃;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 871834-51-4
2-(2-nitro-4-trifluoromethylphenylamino)-butan-1-ol

: 871834-54-7
1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂

2: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

3: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

4: 50 percent / NaCNBH₃ / methanol / 20 - 80 °C

With pyridine; hydrogen; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: 871834-52-5
methanesulfonic acid 2-(2-nitro-4-trifluoromethylphenylamino)-butyl ester

: 871834-54-7
1-(3,5-bis-trifluoromethylbenzyl)-3-ethyl-7-trifluoromethyl-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

2: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

3: 50 percent / NaCNBH₃ / methanol / 20 - 80 °C

With hydrogen; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1016/j.bmcl.2007.01.112