2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Base Information

Chemical Name:2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside
CAS No.:896729-54-7
Molecular Formula:C₃₆H₃₈Cl₃NO₁₂
Molecular Weight:783.056
Hs Code.:

2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Synonyms:2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

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Chemical Property of 2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

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Technology Process of 2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

There total 7 articles about 2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 896729-42-3
(2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2S,4aR,6R,7R,8R,8aR)-6-(naphthalen-2-ylmethoxy)-2-phenyl-7-(2,2,2-trichloro-acetylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-tetrahydro-pyran-2-carboxylic acid methyl ester

: 116-11-0
2-Methoxypropene

: 896729-54-7
2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: With camphor-10-sulfonic acid; In N,N-dimethyl-formamide; for 1.5h;
DOI:10.1002/anie.200503551

Reference yield:

: O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-(1->3)-1,4,6-tri-O-acetyl-2-deoxy-2-trichloroacetamido-D-galactopyranose

: 896729-54-7
2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / n-Bu₄NBr; BF₃*Et₂O; TMSBr / 2,4,6-collidine / CH₂Cl₂ / 48 h / 20 °C

2: 90 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h

3: NaOMe / methanol

4: trifluoroacetic acid / 4 h

5: 83 percent / camphorsulfonic acid / dimethylformamide / 1.5 h

With trimethylsilyl bromide; trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutylammomium bromide; sodium methylate; trifluoroacetic acid; 2,4,6-trimethyl-pyridine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200503551

Reference yield:

: 890131-32-5
O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-(1->3)-2-trichloromethyl-(4,6-di-O-acetyl-1,2-dideoxy-α-D-galactopyrano)[2,1-d]2-oxazoline

: 896729-54-7
2-naphthylmethyl O-(methyl 2,3-O-isopropylidene-β-D-glucopyranosyluronate)-(1->3)-4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h

2: NaOMe / methanol

3: trifluoroacetic acid / 4 h

4: 83 percent / camphorsulfonic acid / dimethylformamide / 1.5 h

With trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; sodium methylate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200503551