tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

Base Information

Chemical Name:tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate
CAS No.:1415354-03-8
Molecular Formula:C₂₉H₃₈N₂O₇
Molecular Weight:526.63
Hs Code.:

Synonyms:tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

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Chemical Property of tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

There total 5 articles about tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415354-02-7
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

: 6482-24-2
2-Bromoethyl methyl ether

: 1415354-03-8
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

Guidance literature:: tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

2-Bromoethyl methyl ether; In N,N-dimethyl-formamide; mineral oil; at 40 ℃; for 1h;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 132118-31-1
2-chloro-8-methoxy-3-methylquinoline

: 1415354-03-8
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1.5 h / Reflux

3.1: ammonium chloride; iron / water; ethanol / 1 h / Reflux

4.1: triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

5.2: 1 h / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 1415353-99-9
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

: 1415354-03-8
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}-N-(2-methoxyethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / water; ethanol / 1 h / Reflux

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 1 h / 40 °C

With iron; sodium hydride; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028