tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

Base Information

Chemical Name:tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate
CAS No.:1415354-02-7
Molecular Formula:C₂₆H₃₂N₂O₆
Molecular Weight:468.55
Hs Code.:

Synonyms:tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

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Chemical Property of tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

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Technology Process of tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

There total 4 articles about tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1415354-00-5
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-amine

: 1415354-02-7
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 132118-31-1
2-chloro-8-methoxy-3-methylquinoline

: 1415354-02-7
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1.5 h / Reflux

3: ammonium chloride; iron / water; ethanol / 1 h / Reflux

4: triethylamine / dichloromethane / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 1415353-99-9
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

: 1415354-02-7
tert-butyl N-{2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; ethanol / 1 h / Reflux

2: triethylamine / dichloromethane / 16 h / 20 °C

With iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028