Technology Process of C28H36N2O3S
There total 9 articles about C28H36N2O3S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C24H34O4;
With
methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 10 - 30 ℃;
for 0.5h;
Cooling with ice;
2-sulfanylpyrimidine;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 9h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate / tetrahydrofuran; methanol / 0.25 h / Reflux
1.2: 1 h / Reflux
2.1: water; sodium carbonate / 5 h / Reflux
3.1: dmap / chloroform; toluene / 1 h / 75 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 10 - 30 °C / Cooling with ice
5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 35 °C
6.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.5 h / 10 - 30 °C / Cooling with ice
6.2: 9 h / 80 °C
With
dmap; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap / chloroform; toluene / 1 h / 75 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 10 - 30 °C / Cooling with ice
3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 35 °C
4.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.5 h / 10 - 30 °C / Cooling with ice
4.2: 9 h / 80 °C
With
dmap; palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine;
In
chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;