3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Base Information

Chemical Name:3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide
CAS No.:1351813-11-0
Molecular Formula:C₂₉H₄₀N₆O₃SSi
Molecular Weight:580.827
Hs Code.:

Synonyms:3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

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Chemical Property of 3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

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Technology Process of 3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

There total 9 articles about 3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1351813-09-6
3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1351813-11-0
3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-04-1
C₁₇H₂₃N₅O₃Si

: 1351813-11-0
3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

3.2: 3 h / Inert atmosphere; Reflux

4.1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

With ethanol; tetrabutyl ammonium fluoride; iodine; sodium tris(acetoxy)borohydride; iron; sodium hydride; ammonium chloride; acetic acid; ethylenediamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-03-0
C₁₃H₁₈BrN₃O₃Si

: 1351813-11-0
3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate / tetrahydrofuran; water / 3.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

3.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

4.2: 3 h / Inert atmosphere; Reflux

5.1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

6.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); ethanol; tetrabutyl ammonium fluoride; iodine; sodium tris(acetoxy)borohydride; iron; sodium hydride; potassium carbonate; ammonium chloride; acetic acid; ethylenediamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1021/jm4000215