3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Base Information

Chemical Name:3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide
CAS No.:1351813-09-6
Molecular Formula:C₂₃H₃₀N₆O₃SSi
Molecular Weight:498.681
Hs Code.:

Synonyms:3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Suppliers and Price of 3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

There total 8 articles about 3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1351813-08-5
3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

: 1351813-09-6
3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: With ethanol; iron; ammonium chloride; In water; for 0.75h; Reflux;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-04-1
C₁₇H₂₃N₅O₃Si

: 1351813-09-6
3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

3.2: 3 h / Inert atmosphere; Reflux

4.1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

With ethanol; tetrabutyl ammonium fluoride; iodine; iron; sodium hydride; ammonium chloride; ethylenediamine; potassium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1021/jm4000215

Reference yield:

: 1351813-03-0
C₁₃H₁₈BrN₃O₃Si

: 1351813-09-6
3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate / tetrahydrofuran; water / 3.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 8 h / Reflux

3.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

4.2: 3 h / Inert atmosphere; Reflux

5.1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); ethanol; tetrabutyl ammonium fluoride; iodine; iron; sodium hydride; potassium carbonate; ammonium chloride; ethylenediamine; potassium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1021/jm4000215