(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester
CAS No.:258354-26-6
Molecular Formula:C₂₁H₂₄ClNO₂
Molecular Weight:357.88
Hs Code.:

Synonyms:(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

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Chemical Property of (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

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Technology Process of (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

There total 3 articles about (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: tert-butyl 2-[(E)-(4-chlorophenyl)methyleneamino]propanoate

: (R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

: 258354-26-6
(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: With cesium hydroxide; (4S,5S)-2-tert-butyl-N,N,N',N'-tetrakis[(4-methoxyphenyl)methyl]-N,N',2-trimethyl-1,3-dioxolane-4,5-dimethanammonium diiodide; In dichloromethane; toluene; at -70 ℃; for 168h; Further Variations:; Reagents; Temperatures; reaction times; Product distribution;
DOI:10.1016/j.tet.2004.05.120

Reference yield:

: 100-39-0
benzyl bromide

: 258354-21-1
tert-butyl (E)-N-(4-chlorobenzylidene)-L-alaninate

: (R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

: 258354-26-6
(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: With potassium hydroxide; N-anthracenylmethyl cinchonidinium chloride; In chloroform; toluene; at 0 ℃; for 24h; Title compound not separated from byproducts.;
DOI:10.1002/ejoc.200700925

Reference yield:

: 100-39-0
benzyl bromide

: (R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

: (R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

: 258354-26-6
(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-2-methyl-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: benzyl bromide; (R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester; With cesium hydroxide; (R,R)-N-spiro quaternary ammonium bromide; In toluene; at -20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; toluene; Title compound not separated from byproducts;
DOI:10.1055/s-2003-41478