Technology Process of (9aR)-8-(3,4-Dimethoxyphenyl)-1,3,4,6,9,9a-hexahydro-7-(4-methoxyphenyl)-2H-quinolizin-6-one
There total 13 articles about (9aR)-8-(3,4-Dimethoxyphenyl)-1,3,4,6,9,9a-hexahydro-7-(4-methoxyphenyl)-2H-quinolizin-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / 5percent aq. NaOH / CH2Cl2 / 0.67 h
2: 79 percent / PDC, 4 Angstroem molecular sieves / CH2Cl2 / 5 h / Ambient temperature
3: 67 percent / 5percent KOH / ethanol / 1 h / Heating
With
potassium hydroxide; sodium hydroxide; dipyridinium dichromate; 4 A molecular sieve;
In
ethanol; dichloromethane;
DOI:10.1021/jo00124a025
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / pyridinium p-toluenesulfonate / 3 h / Ambient temperature
2: BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature
3: 64 percent / BF3*THF / tetrahydrofuran / 1.) room temp., 15 min, 2.) reflux, 24 h
4: 85 percent / 5percent aq. NaOH / CH2Cl2 / 0.67 h
5: 79 percent / PDC, 4 Angstroem molecular sieves / CH2Cl2 / 5 h / Ambient temperature
6: 67 percent / 5percent KOH / ethanol / 1 h / Heating
With
potassium hydroxide; sodium hydroxide; dipyridinium dichromate; boron trifluoride-tetrahydrofuran complex; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00124a025
