(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

Base Information

Chemical Name:(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid
CAS No.:123993-24-8
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

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Chemical Property of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

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Technology Process of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

There total 3 articles about (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 123993-22-6
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

: 123993-24-8
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jo00290a021

Reference yield:

: 19391-35-6
N-tert-butoxycarbonyl-L-tyrosine benzyl ester

: 123993-24-8
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) up to RT, over 1 h

2: 65 percent / LiCl / bis(triphenylphosphine)palladium dichloride / dimethylformamide / 1.5 h / 95 °C

3: 89 percent / H₂ / 10percent Pd/C / ethanol

With hydrogen; triethylamine; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a021

Reference yield:

: 123993-20-4
N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester

: 123993-24-8
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / LiCl / bis(triphenylphosphine)palladium dichloride / dimethylformamide / 1.5 h / 95 °C

2: 89 percent / H₂ / 10percent Pd/C / ethanol

With hydrogen; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a021