α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Base Information

Chemical Name:α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol
CAS No.:1289154-73-9
Molecular Formula:C₂₉H₂₈O₂
Molecular Weight:408.54
Hs Code.:

Synonyms:α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

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Chemical Property of α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Chemical Property:

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Technology Process of α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

There total 4 articles about α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 938-16-9
2,2-dimethylpropiophenone

: 1289154-71-7
C₁₈H₁₄O

: 1289154-73-9
α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: C₁₈H₁₄O; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

2,2-dimethylpropiophenone; In tetrahydrofuran; diethyl ether; hexane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.3762/bjoc.7.58

Reference yield:

: 1289154-69-3
trimethyl[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]silane

: 1289154-73-9
α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / methanol; diethyl ether / 0.5 h / 20 °C

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With n-butyllithium; water; sodium hydroxide; In methanol; diethyl ether; hexane;
DOI:10.3762/bjoc.7.58

Reference yield:

: 137648-47-6
1-iodo-2-ethynylbenzene

: 1289154-73-9
α-[[2-[[2-(methoxymethyl)phenyl]ethynyl]phenyl]ethynyl]-α-(1,1-dimethylethyl)benzenemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / toluene / 5 h / 70 °C

2.1: water; sodium hydroxide / methanol; diethyl ether / 0.5 h / 20 °C

3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; bis(triphenylphosphine)palladium(II) dichloride; water; triethylamine; sodium hydroxide; In methanol; diethyl ether; hexane; toluene; 1.1: Sonogashira reaction;
DOI:10.3762/bjoc.7.58