(S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Base Information

• Chemical Name: (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
• CAS No.: 33770-43-3
• Molecular Formula: C₁₉H₂₃NO₄
• Molecular Weight: 329.396

Synonyms:(S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Chemical Property of (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Technology Process of (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

There total 28 articles about (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline (15547-57-6) → (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (33770-43-3)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₂H₄₆FeP₂; hydrogen bromide; hydrogen; In tetrahydrofuran; water; at 30 ℃; for 12h; under 38002.6 Torr; enantioselective reaction; Schlenk technique; Autoclave;

DOI:10.1021/acs.orglett.9b03251

Reference yield: 95.0%

(1S,1'R)-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline (132283-76-2) → (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (33770-43-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0040-4020(01)87916-3

Reference yield: 95.0%

(S)-2-[(S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-ethanol (170711-00-9) → (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (33770-43-3)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jo00127a006

upstream raw materials:

1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

(1S,1'R)-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

(S)-2-[(S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-ethanol

methyl (3,4-dimethoxyphenyl)acetate

Downstream raw materials:

(S)-1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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