Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-

Base Information

• Chemical Name: Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-
• CAS No.: 22324-82-9
• Molecular Formula: C20H25 N O4
• Molecular Weight: 343.423
• Mol file: 22324-82-9.mol

Synonyms:CryptostylineII (8CI); Isoquinoline, 1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(S)-; (+)-Cryptostyline II; (S)-Cryptostyline II; S-(+)-Cryptostyline II

Chemical Property of Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-

There total 13 articles about Isoquinoline,1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C24H33NO7 → (S)-1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (22324-82-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 12h; enantioselective reaction;

DOI:10.1021/acs.orglett.7b00776

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (33770-43-3) → (S)-1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (22324-82-9)

Guidance literature:

With formic acid;

DOI:10.1021/jo00127a006

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + formic acid (64-18-6) + 12,13-bisepieupalmerin (52239-68-6,92693-30-6) → (S)-1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (22324-82-9)

Guidance literature:

at 90 - 95 ℃; for 2.5h;

DOI:10.1016/S0040-4020(01)87916-3

upstream raw materials:

formaldehyd

formic acid

12,13-bisepieupalmerin

(S)-1-1-(3',4'-dimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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