4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 209808-17-3
• Molecular Formula: C₁₈H₂₂BrNO₄
• Molecular Weight: 396.281

Synonyms:4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

4-[Bromo(1-Boc-piperidin-4-ylidene)methyl]benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-Bromo-4-[bromo-(4-methoxycarbonyl-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (209808-16-2) → 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester (209808-17-3)

Guidance literature:

With methanol; sodium hydroxide; at 40 ℃; for 3h;

DOI:10.1021/jm000229p

Reference yield:

4-[bromo-(4-carboxy-phenyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester → 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester (209808-17-3)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 40 ℃; for 3h; pH=2;

Reference yield:

4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester (209808-15-1) → 4-[bromo-(4-carboxyphenyl)methylene]-piperidine-1-carboxylic acid tert-butyl ester (209808-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Br₂; K₂CO₃ / CH₂Cl₂ / 1.5 h / 20 °C

2: 87 percent / 2 M NaOH; MeOH / 3 h / 40 °C

With methanol; sodium hydroxide; bromine; potassium carbonate; In dichloromethane;

DOI:10.1021/jm000229p

upstream raw materials:

4-Bromo-4-[bromo-(4-methoxycarbonyl-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester

4-methyl-benzoic acid methyl ester

Downstream raw materials:

4-[Bromo-(4-diethylcarbamoyl-phenyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-[bromo({4-[(2-hydroxyethyl)(methyl)carbamoyl]phenyl})methylidene]piperidine-1-carboxylate

C₃₂H₄₀F₃N₃O₄

C₃₄H₄₅N₃O₇

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