1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

Base Information

• Chemical Name: 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole
• CAS No.: 102792-24-5
• Molecular Formula: C₁₂H₁₁BrF₃N₃
• Molecular Weight: 334.139
• Mol file: 102792-24-5.mol

Synonyms:1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

Chemical Property of 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

There total 5 articles about 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1-<4-Amino-3-(trifluoromethyl)phenyl>-2,4-dimethylimidazole (102792-18-7) → 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole (102792-24-5)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid; at 70 ℃; for 3h;

DOI:10.1021/jm00123a011

Reference yield:

sodium carbonate (497-19-8) + 1-<4-Amino-3-(trifluoromethyl)phenyl>-2,4-dimethylimidazole (102792-18-7) → 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole (102792-24-5)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid;

Reference yield:

2,4-Dimethylimidazole (930-62-1) → 1-<4-Amino-3-bromo-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole (102792-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂CO₃ / dimethylformamide / 100 °C

2: 99 percent / hydrogen / 5 percent Pd/charcoal / ethanol / 16 h / 50 °C / 2585.7 Torr

3: 36 percent / bromine, HBr / acetic acid / 3 h / 70 °C

With hydrogen bromide; hydrogen; bromine; sodium carbonate; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a011

upstream raw materials:

1-<4-Amino-3-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

2,4-Dimethylimidazole

4-fluoro-1-nitro-2-trifluoromethyl-benzene

1-(4-nitro-3-trifluoromethylphenyl)-2,4-dimethylimidazole

Downstream raw materials:

1-<4-Amino-3-cyano-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole

1-<4-Amino-3-formyl-5-(trifluoromethyl)phenyl>-2,4-dimethylimidazole