Technology Process of N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide
There total 6 articles about N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 15 h / 20 °C
2: dichloromethane / 15 h / 20 °C
3: trichlorophosphate / toluene / 15 h / 110 °C
4: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux
5: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr
6: 1 h / 100 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; oxalyl dichloride; palladium diacetate; triethylamine hydrochloride; triethylamine; trichlorophosphate;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b01434
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dichloromethane / 15 h / 20 °C
2: trichlorophosphate / toluene / 15 h / 110 °C
3: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux
4: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr
5: 1 h / 100 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; palladium diacetate; triethylamine hydrochloride; triethylamine; trichlorophosphate;
In
dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.5b01434