Technology Process of 4-(1-phenethyl-1,2,3-triazol-4-yl)-2-nitroaniline
There total 3 articles about 4-(1-phenethyl-1,2,3-triazol-4-yl)-2-nitroaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-phenyl-2-bromoethane;
With
sodium azide;
In
dimethyl sulfoxide;
at 20 ℃;
for 24h;
4-ethynyl-2-nitroaniline;
With
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
at 20 ℃;
for 3h;
DOI:10.1021/jm4001709
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / dichloromethane / 5 h / 20 °C
3.1: sodium azide / dimethyl sulfoxide / 24 h / 20 °C
3.2: 3 h / 20 °C
With
methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm4001709
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; methanol / dichloromethane / 5 h / 20 °C
2.1: sodium azide / dimethyl sulfoxide / 24 h / 20 °C
2.2: 3 h / 20 °C
With
methanol; sodium azide; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm4001709
