518982-26-8Relevant articles and documents
Bridging ligand length controls at selectivity and enantioselectivity of binuclear ruthenium threading intercalators
Johansson, Johan R.,Wang, Yubo,Eng, Mattias P.,Kann, Nina,Lincoln, Per,Andersson, Johanna
, p. 6246 - 6256 (2013)
The slow dissociation of DNA threading intercalators makes them interesting as model compounds in the search for new DNA targeting drugs, as there appears to be a correlation between slow dissociation and biological activity. Thus, it would be of great value to understand the mechanisms controlling threading intercalation, and for this purpose we have investigated how the length of the bridging ligand of binuclear ruthenium threading intercalators affects their DNA binding properties. We have synthesised a new binuclear ruthenium threading intercalator with slower dissociation kinetics from ct-DNA than has ever been observed for any ruthenium complex with any type of DNA, a property that we attribute to the increased distance between the ruthenium centres of the new complex. By comparison with previously studied ruthenium complexes, we further conclude that elongation of the bridging ligand reduces the sensitivity of the threading interaction to DNA flexibility, resulting in a decreased AT selectivity for the new complex. We also find that the length of the bridging ligand affects the enantioselectivity with increasing preference for the ΔΔ enantiomer as the bridging ligand becomes longer. Copyright
PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE
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Paragraph 0090, (2017/07/06)
A phosphorescent transition metal complex especially suitable as sensor for hydrogen peroxide in cells, in particular in mitochondria in live cells, includes a metallic central atom, which is a transition metal, a first ligand with at least one pyridine r
Effect of head group size on the photoswitching applications of azobenzene Disperse Red 1 analogues
Goulet-Hanssens, Alexis,Corkery, T. Christopher,Priimagi, Arri,Barrett, Christopher J.
supporting information, p. 7505 - 7512 (2014/11/08)
We investigate the effect of the increased molecular bulk in the 'head' group for a class of newly synthesized azobenzene chromophores with a clickable ethynyl group para and a nitro group ortho to the azo bond on the distal benzene ring. This 'variable-head' functionalization provides a family of dyes with photophysical characteristics very similar to those of Disperse Red 1, one of the most commonly used azo dyes in materials science. Phenyl, naphthyl, and anthracyl derivatives were synthesized as small molecules, monomers, homopolymers, and copolymers in a rapid and facile manner using click chemistry, confirming the versatility of this parent chromophore. Photochemical and spectral studies indicate that this strategy is suitable to build a 'bulkiness series' of stimuli-responsive materials, as the various material derivatives retain the absorption and kinetic characteristics of the parent chromophore necessary for all optical patterning applications that DR1 dyes have been optimized for. In thin films, larger head group size was found to increase the stability of light-induced birefringence in copolymers. The homopolymers formed stable surface-relief gratings upon interference irradiation, whose grating depths correlate with head group size, demonstrating that this new class of polymers can also undergo tailored macroscopic photoinduced motions, which could have applications in all optical nano-patterning. the Partner Organisations 2014.
