tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate
CAS No.:1350881-15-0
Molecular Formula:C₂₅H₂₉FN₂O₄S
Molecular Weight:472.581
Hs Code.:

Synonyms:tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

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Chemical Property of tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

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Technology Process of tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

There total 7 articles about tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350881-30-9
4-(tert-butoxycarbonyl)-5-(2-phenylethyl)morpholine-2-carboxylic acid

: 22179-72-2
4-fluorothiobenzamide

: 1350881-15-0
tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

Guidance literature:: 4-(tert-butoxycarbonyl)-5-(2-phenylethyl)morpholine-2-carboxylic acid; With HATU; In dichloromethane; at 20 ℃; for 0.333333h;

4-fluorothiobenzamide; In dichloromethane; at 20 ℃; for 0.666667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1350881-15-0
tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; 3-ethylbenzothiazolium bromide / ethanol / 70 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3.1: dichloromethane

4.1: triphenylphosphine; diethylazodicarboxylate / toluene / 20 °C

5.1: hydrogen / palladium on activated charcoal / ethanol / 2327.23 Torr

6.1: Jones reagent / acetone / 0 - 20 °C

7.1: HATU / dichloromethane / 0.33 h / 20 °C

7.2: 0.67 h / 20 °C

7.3: 20 °C

With Jones reagent; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; 3-ethylbenzothiazolium bromide; HATU; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetone; toluene;

Reference yield:

: 20296-07-5
1-hydroxy-4-phenyl-2-butanone

: 1350881-15-0
tert-butyl 2-{[(4-fluorophenyl)carbonothioyl]carbamoyl}-5-(2-phenylethyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2.1: dichloromethane

3.1: triphenylphosphine; diethylazodicarboxylate / toluene / 20 °C

4.1: hydrogen / palladium on activated charcoal / ethanol / 2327.23 Torr

5.1: Jones reagent / acetone / 0 - 20 °C

6.1: HATU / dichloromethane / 0.33 h / 20 °C

6.2: 0.67 h / 20 °C

6.3: 20 °C

With Jones reagent; hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; HATU; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetone; toluene;