[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

Base Information

Chemical Name:[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester
CAS No.:669065-50-3
Molecular Formula:C₄₃H₆₇NO₆SSi₂
Molecular Weight:782.245
Hs Code.:

Synonyms:[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

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Chemical Property of [1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

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Technology Process of [1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

There total 3 articles about [1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 669065-41-2
[1(1S,2R),2S,3S]-5-(tert-butyl-dimethylsilyloxy)-3-hydroxy-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

: 669065-50-3
[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; γ-Irradiation;
DOI:10.1021/ol036284k

Reference yield:

: 89922-82-7
3-(tert-butyldimethylsilanyloxy)propionaldehyde

: 669065-50-3
[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; Cy₂BOTf / CH₂Cl₂; hexane / 2 h / -78 °C

1.2: 94 percent / CH₂Cl₂; hexane / 2 h / -78 - 20 °C

2.1: 96 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C / γ-Irradiation

With 2,6-dimethylpyridine; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane;
DOI:10.1021/ol036284k

Reference yield:

: 187324-67-0
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate

: 669065-50-3
[1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; Cy₂BOTf / CH₂Cl₂; hexane / 2 h / -78 °C

1.2: 94 percent / CH₂Cl₂; hexane / 2 h / -78 - 20 °C

2.1: 96 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C / γ-Irradiation

With 2,6-dimethylpyridine; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane;
DOI:10.1021/ol036284k