669065-41-2

Upstream product

• 89922-82-7 3-(tert-butyldimethylsilanyloxy)propionaldehyde 
• 187324-67-0 (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate 

Downstream Products

• 669065-53-6 [1(1RS,3Z,5R,6S,7S),3R]-N-{3-[1-benzenesulfonyl-7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 
• 669065-54-7 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-44-5 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 
• 669065-55-8 [1(3Z,5R,6S,7S),3R]-N-{3-[7-(tert-butyl-dimethylsilyloxy)-9-hydroxy-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-hydroxy-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-45-6 [1(3Z,5R,6S,7S),3R]-N-{3-[7-(tert-butyl-dimethylsilyloxy)-9-oxo-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-3-methoxy-4-oxo-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-35-4 [1(3Z,5R,6S,7S,9E),3R,4E]-3-methoxy-hepta-4,6-dienoic acid {3-[7-(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-dodeca-3,9,11-trienyl]-2,5-dimethoxy-phenyl}-amide 
• 669065-51-4 (2Z,4R,5S,6S)-6,8-bis(tert-butyl-dimethylsilyloxy)-1-(4-methoxybenzyloxy)-3,5-dimethyl-4-triisopropylsilyloxy-oct-2-ene 
• 669065-43-4 (2Z,4R,5R,6S)-6,8-bis(tert-butyl-dimethylsilyloxy)-1-(4-methoxybenzyloxy)-3,5-dimethyloct-2-en-4-ol 
• 669065-50-3 [1(1S,2R),2S,3S]-3,5-bis(tert-butyl-dimethylsilyloxy)-2-methylpentanoic acid 2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-propyl ester 

Relevant academic research and scientific papers

A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization

(Equation presented) The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A-D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam.