(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

Base Information

Chemical Name:(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol
CAS No.:331627-27-1
Molecular Formula:C₂₂H₃₆O₂SSi
Molecular Weight:392.678
Hs Code.:

Synonyms:(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

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Technology Process of (1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

There total 4 articles about (1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 331627-34-0
4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-3-(2-phenylsulfanyl-ethyl)-cyclohex-2-enone

: 331627-27-1
(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

: 331627-59-9
(1S,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;
DOI:10.1021/jo0015772

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 331627-27-1
(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / 10 h / 20 °C

2: 21.6 g / tetrahydrofuran / 6 h / 0 °C

3: 93 percent / Et₃N / benzene / 1 h / 20 °C

4: 8.76 g / DIBAL-H / toluene / 0.5 h / -78 °C

With 1H-imidazole; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo0015772

Reference yield:

: 252979-17-2
(S)-6-hydroxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone

: 331627-27-1
(1R,4R)-4-tert-butyldimethylsilyloxymethyl-4-methyl-3-(2-phenylthioethyl)-2-cyclohexenol

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / 10 h / 20 °C

2: 21.6 g / tetrahydrofuran / 6 h / 0 °C

3: 93 percent / Et₃N / benzene / 1 h / 20 °C

4: 8.76 g / DIBAL-H / toluene / 0.5 h / -78 °C

With 1H-imidazole; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo0015772