15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one

Base Information Edit

Chemical Name:15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one
CAS No.:67372-65-0
Molecular Formula:C20H28 O2
Molecular Weight:300.441
Hs Code.:
Nikkaji Number:J2.320.815F
Mol file:67372-65-0.mol

Synonyms:SCHEMBL3236495;AXAHTJKCKWRAAM-HOKJGMFHSA-N;15beta,16beta-methylene-3beta-hydroxyandrost-5-en-17-one;3beta-hydroxy-15beta,16beta-methylene-5-androsten-17-one

Suppliers and Price of 15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
15,16-DIHYDRO-3-HYDROXY-3'H-CYCLOPROP[15,16]ANDROSTA-5,15-DIEN-17-ONE 95.00%
5MG
$ 498.17

Total 9 raw suppliers

Chemical Property of 15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one Edit

Chemical Property:

Boiling Point:441.9 °C at 760 mmHg
Flash Point:188.4 °C
PSA：37.30000
Density:1.17 g/cm³
LogP:3.73510
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:300.208930132
Heavy Atom Count:22
Complexity:578

Purity/Quality:

99% ^*data from raw suppliers

15,16-DIHYDRO-3-HYDROXY-3'H-CYCLOPROP[15,16]ANDROSTA-5,15-DIEN-17-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(CC1=CCC3C2CCC4(C3C5CC5C4=O)C)O
Isomeric SMILES:C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3[C@@H]5C[C@@H]5C4=O)C)O

Technology Process of 15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one

There total 5 articles about 15beta,16beta-Methylene-3beta-hydroxyandrost-5-en-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 17921-64-1
(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

: 1774-47-6
trimethylsulfoxonium iodide

: 67372-65-0
3β-hydorxy-15β,16β-methylene androst-5-ene-17-one

Guidance literature:: With sodium hydride; 1.) DMSO, 20 deg C, 2.) 2 h;
DOI:10.1007/BF00948530

Reference yield:

: 26441-36-1
15β,16β-methylenoandrost-5-en-3β-ol-17-one acetate

: 67372-65-0
3β-hydorxy-15β,16β-methylene androst-5-ene-17-one

Guidance literature:: With alkali; In ethanol;
DOI:10.1007/BF00948530

Reference yield:

: 17921-64-1
(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

: 67372-65-0
3β-hydorxy-15β,16β-methylene androst-5-ene-17-one

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / diethyl ether / 14 h / 20 °C / 750.06 Torr

2: 23 percent / BF₃*Et₂O / acetone / 1 h / 20 °C

3: alkali / aq. ethanol

With boron trifluoride diethyl etherate; In diethyl ether; ethanol; acetone;
DOI:10.1007/BF00948530