1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester
• CAS No.: 1415678-05-5
• Molecular Formula: C₁₈H₂₃ClO₉S₂
• Molecular Weight: 482.96
• Mol file: 1415678-05-5.mol

Synonyms:1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester

Chemical Property of 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester

There total 2 articles about 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(4-chlorobenzyl)-3,3-bis(hydroxymethyl)-2-oxocyclopentane carboxylic acid methyl ester (1311402-88-6) + methanesulfonyl chloride (124-63-0) → 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester (1415678-05-5)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; toluene; at 20 ℃; for 1.5h; Cooling with ice;

Reference yield:

1-[(4-chlorophenyl)methyl]-2-oxocyclopentanecarboxylic acid methyl ester (115851-73-5) → 1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester (1415678-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water; tetrahydrofuran / 5 h / 20 °C

2: triethylamine / toluene; N,N-dimethyl acetamide / 1.5 h / 20 °C / Cooling with ice

With potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; water; toluene;

Reference yield: 41.0%

1-(4-chlorobenzyl)-3,3-bis(methanesulfonyloxymethyl)-2-oxocyclopentanecarboxylic acid methyl ester (1415678-05-5) → 5-(4-chlorobenzyl)-2,2-bis(methanesulfonyloxymethyl)cyclopentanone (1415678-06-6)

Guidance literature:

With methanesulfonic acid; In water; at 100 ℃; for 7h;

upstream raw materials:

1-[(4-chlorophenyl)methyl]-2-oxocyclopentanecarboxylic acid methyl ester

1-(4-chlorobenzyl)-3,3-bis(hydroxymethyl)-2-oxocyclopentane carboxylic acid methyl ester

methanesulfonyl chloride

Downstream raw materials:

5-(4-chlorobenzyl)-2,2-bis(methanesulfonyloxymethyl)cyclopentanone