tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester

Base Information

• Chemical Name: tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester
• CAS No.: 473919-02-7
• Molecular Formula: C₁₇H₂₆NO₈P
• Molecular Weight: 403.369
• Mol file: 473919-02-7.mol

Synonyms:tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester

Chemical Property of tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester

There total 1 articles about tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(±)-2-((tert-butoxycarbonyl)amino)-2-(dimethoxyphosphoryl)acetic acid (121056-96-0) + 4-Methoxybenzyl alcohol (105-13-5) → tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester (473919-02-7)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/ol026694t

Reference yield: 70.0%

tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester (473919-02-7) + 4-[2-benzyloxy-3-(2-trimethylsilanyl-ethoxycarbonyl)-phenyl]-3-formyl-indole-1-carboxylic acid benzyl ester (473918-97-7) → 4-[2-benzyloxy-3-(2-trimethylsilanyl-ethoxycarbonyl)-phenyl]-3-[2-tert-butoxycarbonylamino-2-(4-methoxy-benzyloxycarbonyl)-vinyl]-indole-1-carboxylic acid benzyl ester

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;

DOI:10.1021/ol026694t

Reference yield:

tert-butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid 4-methoxy-benzyl ester (473919-02-7) → 3-[3-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-1H-indol-4-yl]-2-hydroxy-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: 70 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂

2.1: hydrogen / Rh((S,S)-DuPHOS)

2.2: 82 percent / hydrogen / Pd/CaCO₃

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; Rh((S,S)-DuPHOS); In dichloromethane; 1.1: Emmons-Horner reaction; Wittig reaction;

DOI:10.1021/ol026694t

upstream raw materials:

(±)-2-((tert-butoxycarbonyl)amino)-2-(dimethoxyphosphoryl)acetic acid

4-Methoxybenzyl alcohol