(2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester

Base Information

• Chemical Name: (2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester
• CAS No.: 1256245-92-7
• Molecular Formula: C₃₀H₄₆O₅Si
• Molecular Weight: 514.778
• Mol file: 1256245-92-7.mol

Synonyms:(2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester

Chemical Property of (2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester

There total 1 articles about (2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(Z)-(R)-5-(tert-butyldiphenylsilanyloxy)dodec-2-enoic acid ethyl ester (1256245-91-6) → (2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester (1256245-92-7)

Guidance literature:

With methanesulfonamide; AD-mix-α; water; In tert-butyl alcohol; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2010.07.026

Reference yield: 92.0%

(2S,3S,5R)-5-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxydodecanoic acid ethyl ester (1256245-92-7) + 2,2-dimethoxy-propane (77-76-9) → (4S,5S)-5-[(R)-2-(tert-butyldiphenylsilanyloxy)nonyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester (1256245-93-8)

Guidance literature:

With CSA; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetasy.2010.07.026

upstream raw materials:

(Z)-(R)-5-(tert-butyldiphenylsilanyloxy)dodec-2-enoic acid ethyl ester

Downstream raw materials:

(4S,5S)-5-[(R)-2-(tert-butyldiphenylsilanyloxy)nonyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester