prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

Base Information

Chemical Name:prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate
CAS No.:1612155-90-4
Molecular Formula:C₃₁H₃₀N₄O₆S
Molecular Weight:586.668
Hs Code.:

Synonyms:prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

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Chemical Property of prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

Chemical Property:

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Technology Process of prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

There total 8 articles about prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₈N₄O₆S

: 107-19-7
propargyl alcohol

: 1612155-90-4
prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.04.102

Reference yield:

: 92-84-2
10H-phenothiazine

: 1612155-90-4
prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

Guidance literature:: Multi-step reaction with 8 steps

1: N-benzyl-trimethylammonium hydroxide / 2 h / 0 °C / Reflux

2: water; sodium hydroxide / methanol / 15 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

4: triethylamine / dichloromethane / 24 h / 20 °C

5: water; sodium hydroxide / 80 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

7: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With water; N-benzyl-trimethylammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.102

Reference yield:

: 136832-74-1
2,5-dioxopyrrolidin-1-yl 3-(10H-phenothiazin-10-yl)propanoate N-hydroxysuccinimide ester

: 1612155-90-4
prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 24 h / 20 °C

2: water; sodium hydroxide / 80 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.102