2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

Base Information

Chemical Name:2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol
CAS No.:1363134-56-8
Molecular Formula:C₂₆H₂₆F₂N₄O₃
Molecular Weight:480.514
Hs Code.:

Synonyms:2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

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Chemical Property of 2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

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Technology Process of 2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

There total 13 articles about 2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1363144-48-2
ethyl 8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate

: 75-16-1
methylmagnesium bromide

: 1363134-56-8
2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2016.05.040

Reference yield:

: 1363144-48-2
ethyl 8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate

: 1363134-56-8
2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

Guidance literature:: With methylmagnesium bromide; In tetrahydrofuran; for 1h; Inert atmosphere; Cooling with ice;

Reference yield:

: 129409-55-8
ethyl 2-(3,4-difluorophenyl)acetate

: 1363134-56-8
2-{8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Reflux

2.1: sodium ethanolate / tert-butyl alcohol / 0.5 h / 20 - 40 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogen; ammonia / Raney cobalt / ethanol / 72 h / 20 °C

4.1: Lawessons reagent / toluene / 4 h / 20 - 110 °C

5.1: acetonitrile / 20 - 50 °C

5.2: 20 - 90 °C

6.1: methylmagnesium bromide / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

With Lawessons reagent; methylmagnesium bromide; ammonia; hydrogen; sodium ethanolate; sodium hydride; Raney cobalt; In tetrahydrofuran; ethanol; toluene; acetonitrile; mineral oil; tert-butyl alcohol;