(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Base Information

Chemical Name:(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
CAS No.:310882-25-8
Molecular Formula:C₂₀H₂₃F₂N₃O₂
Molecular Weight:375.418
Hs Code.:

Synonyms:(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

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Chemical Property of (2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

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Technology Process of (2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

There total 3 articles about (2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 58009-93-1
3-methyl-2-oxo-butylphosphonic acid dimethyl ester

: 310882-12-3
(2R-cis)-2-(2,4-difluorophenyl)-4-formylmethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-25-8
(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Guidance literature:: With 1,8-diazabicyclo[5.4.0]-undecen-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: 149809-43-8
(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-25-8
(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 84.5 percent / dimethylsulfoxide / 15 h / 55 °C

2: 52.1 percent / diisobutylaluminum hydride / toluene / -78 - 20 °C

3: 90.9 percent / 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

With 1,8-diazabicyclo[5.4.0]-undecen-7-ene; diisobutylaluminium hydride; lithium chloride; In dimethyl sulfoxide; toluene; acetonitrile; 1: Substitution / 2: Reduction / 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: 310882-09-8
(2R-cis)-4-cyanomethyl-2-(2,4-difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-25-8
(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 52.1 percent / diisobutylaluminum hydride / toluene / -78 - 20 °C

2: 90.9 percent / 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

With 1,8-diazabicyclo[5.4.0]-undecen-7-ene; diisobutylaluminium hydride; lithium chloride; In toluene; acetonitrile; 1: Reduction / 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0968-0896(00)00177-2