2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

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Chemical Name:2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol
CAS No.:1616406-27-9
Molecular Formula:C₂₀H₂₁Cl₂N₃O
Molecular Weight:390.312
Hs Code.:

Synonyms:2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

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Chemical Property of 2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

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Technology Process of 2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

There total 5 articles about 2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616406-26-8
2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-one

: 1616406-27-9
2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jm500535j

Reference yield:

: 1616406-23-5
4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazole

: 1616406-27-9
2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

2: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1021/jm500535j

Reference yield:

: 69267-75-0
2-bromo-1-cyclopropylethan-1-one

: 1616406-27-9
2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

2: acetic acid / 2 h / 150 °C / Microwave irradiation; Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

4: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm500535j