2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

Base Information

Chemical Name:2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol
CAS No.:1616405-84-5
Molecular Formula:C₁₄H₁₅Cl₂N₃O
Molecular Weight:312.199
Hs Code.:

Synonyms:2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

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Chemical Property of 2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

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Technology Process of 2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

There total 6 articles about 2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1616406-27-9
2-(4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-ol

: 1616405-84-5
2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

Guidance literature:: With hydroxylamine hydrochloride; In ethanol; at 150 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm500535j

Reference yield:

: 69267-75-0
2-bromo-1-cyclopropylethan-1-one

: 1616405-84-5
2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

2: acetic acid / 2 h / 150 °C / Microwave irradiation; Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

4: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

5: hydroxylamine hydrochloride / ethanol / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium tetrahydroborate; hydroxylamine hydrochloride; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm500535j

Reference yield:

: 1616406-23-5
4-cyclopropyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-imidazole

: 1616405-84-5
2-(2-amino-4-cyclopropyl-1H-imidazol-1-yl )-1-(2,4-dichlorophenyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

2: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C / Inert atmosphere

3: hydroxylamine hydrochloride / ethanol / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium tetrahydroborate; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm500535j