2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

Base Information

Chemical Name:2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol
CAS No.:895153-61-4
Molecular Formula:C₁₅H₂₂O₂Si
Molecular Weight:262.424
Hs Code.:

Synonyms:2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

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Chemical Property of 2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

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Technology Process of 2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

There total 3 articles about 2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 492440-32-1
Dimethyl-phenyl-[(R)-5-vinyl-dihydro-furan-(3Z)-ylidenemethyl]-silane

: 895153-61-4
2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

Guidance literature:: Dimethyl-phenyl-[(R)-5-vinyl-dihydro-furan-(3Z)-ylidenemethyl]-silane; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ja060812g

Reference yield:

: 43019-63-2
3-(phenyldimethylsilyl)prop-2-yn-1-ol

: 895153-61-4
2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: [CpRu(CH₃CN)3]PF₆ / acetone / 3 h / 20 °C

2.1: Pd₂(dba)3*CHCl₃; diphenylphosphinobenzoic acid based chiral ligand; Et₃N / NBu₄Cl / CH₂Cl₂ / 2 h / 0 °C

3.1: 9-BBN / tetrahydrofuran / 2 h / 20 °C

3.2: aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 9-borabicyclo[3.3.1]nonane dimer; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; diphenylphosphinobenzoic acid based chiral ligand; triethylamine; tetrabutyl-ammonium chloride; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ja060812g

Reference yield:

: (E)-2-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-6-(4-nitro-phenoxy)-hex-4-en-1-ol

: 895153-61-4
2-{(R)-4-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pd₂(dba)3*CHCl₃; diphenylphosphinobenzoic acid based chiral ligand; Et₃N / NBu₄Cl / CH₂Cl₂ / 2 h / 0 °C

2.1: 9-BBN / tetrahydrofuran / 2 h / 20 °C

2.2: aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 9-borabicyclo[3.3.1]nonane dimer; diphenylphosphinobenzoic acid based chiral ligand; triethylamine; tetrabutyl-ammonium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja060812g