N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide

Base Information

• Chemical Name: N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide
• CAS No.: 121876-67-3
• Molecular Formula: C₂₂H₁₈N₄O₄
• Molecular Weight: 402.409

Synonyms:N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide

Chemical Property of N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide

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Technology Process of N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide

There total 6 articles about N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-phenyl-2-ethoxycarbonylmethyl-3-dicyanomethylene-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide (121876-63-9) → N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.02,6>undec-3,5,8-triene-10,11-exo-dicarboximide (121876-67-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 10h;

Reference yield: 84.0%

N-phenyl-2-ethoxycarbonylmethyl-3-dicyanomethylene-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide (121876-63-9) → C22H18N4O4 (121876-67-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 10h;

DOI:10.3987/COM-88-S20

Reference yield:

2-dicyanomethylene-1,2-dihydro-1-ethoxycarbonylmethylpyridine (121876-59-3) → C22H18N4O4 (121876-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 34 percent / 72 h / 95 - 100 °C

2: 84 percent / triethylamine / dimethylformamide / 10 h / 60 - 70 °C

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.3987/COM-88-S20

upstream raw materials:

N-phenyl-2-ethoxycarbonylmethyl-3-dicyanomethylene-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide

2-hydroxypyridin

(2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester

2-dicyanomethylene-1,2-dihydro-1-ethoxycarbonylmethylpyridine

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