1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

Base Information

Chemical Name:1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione
CAS No.:313336-66-2
Molecular Formula:C₂₂H₂₁N₃O₃
Molecular Weight:375.427
Hs Code.:

Synonyms:1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

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Technology Process of 1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

There total 3 articles about 1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 201230-82-2
carbon monoxide

: 85092-84-8
3-iodo-1-methyl-1H-indole

: 13754-38-6
N-Benzoylpiperazine

: 313336-66-2
1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

Guidance literature:: With palladium diacetate; sodium carbonate; at 50 ℃; for 9h; chemoselective reaction;
DOI:10.1021/acs.joc.5b01249

Reference yield: 60.0%

: 603-76-9
1-methylindole

: 201230-82-2
carbon monoxide

: 13754-38-6
N-Benzoylpiperazine

: 313336-66-2
1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

Guidance literature:: 1-methylindole; With iodine; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 3h; Autoclave;

carbon monoxide; N-Benzoylpiperazine; With copper(l) iodide; cis-dichlorobis(benzonitrile)palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium chloride; In tetrahydrofuran; at 60 ℃; under 30402 Torr; regioselective reaction; Autoclave;
DOI:10.1039/c2cc36341k

Reference yield:

: BMS-216

: 313336-66-2
1-(4-benzoylpiperazin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2009.02.040