N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

Base Information

Chemical Name:N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide
CAS No.:1415345-29-7
Molecular Formula:C₃₀H₃₅Cl₂N₅O₃Si
Molecular Weight:612.631
Hs Code.:

Synonyms:N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

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Chemical Property of N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

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Technology Process of N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

There total 6 articles about N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1415345-28-6
1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1415345-29-7
N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 6h;

Reference yield:

: 879548-01-3
1-allyl-5-nitro-1,2-dihydro-indazol-3-one

: 1415345-29-7
N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 16 h / 20 °C

2.1: ammonium chloride; iron / ethanol; water / 4 h / Reflux

3.1: potassium carbonate / acetonitrile / 24 h / Reflux

4.1: triethylamine / dichloromethane / 6 h / 0 °C

With iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 61346-19-8
5-nitroindazolin-3-one

: 1415345-29-7
N-(1-allyl-2-benzyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / water / 2 h / Reflux

1.2: 1 h / Reflux

1.3: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

2.2: 16 h / 20 °C

3.1: ammonium chloride; iron / ethanol; water / 4 h / Reflux

4.1: potassium carbonate / acetonitrile / 24 h / Reflux

5.1: triethylamine / dichloromethane / 6 h / 0 °C

With iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;