1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

Base Information

Chemical Name:1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one
CAS No.:1415345-28-6
Molecular Formula:C₂₅H₃₅N₃O₂Si
Molecular Weight:437.657
Hs Code.:

Synonyms:1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

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Chemical Property of 1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

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Technology Process of 1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

There total 5 articles about 1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1415345-27-5
1-allyl-5-amino-2-benzyl-1H-indazol-3(2H)-one

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1415345-28-6
1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Reflux;

Reference yield:

: 879548-01-3
1-allyl-5-nitro-1,2-dihydro-indazol-3-one

: 1415345-28-6
1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 16 h / 20 °C

2.1: ammonium chloride; iron / ethanol; water / 4 h / Reflux

3.1: potassium carbonate / acetonitrile / 24 h / Reflux

With iron; sodium hydride; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 61346-19-8
5-nitroindazolin-3-one

: 1415345-28-6
1-allyl-2-benzyl-5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1H-indazol-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / water / 2 h / Reflux

1.2: 1 h / Reflux

1.3: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

2.2: 16 h / 20 °C

3.1: ammonium chloride; iron / ethanol; water / 4 h / Reflux

4.1: potassium carbonate / acetonitrile / 24 h / Reflux

With iron; sodium hydride; potassium carbonate; ammonium chloride; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;