(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:189007-62-3
Molecular Formula:C₃₂H₄₀N₂O₇Si
Molecular Weight:592.764
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 28252-50-8
N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH

: 189007-62-3
(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/0040-4039(96)00582-5

Reference yield: 90.0%

: 189007-62-3
(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

: 178361-86-9
(S)-2-Amino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1016/0040-4039(96)00582-5

Reference yield:

: 189007-62-3
(S)-2-Benzyloxycarbonylamino-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

: 178361-87-0
(S)-2-[(2R,3R)-2-Amino-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-N-[bis-(4-methoxy-phenyl)-methyl]-succinamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / Pd/C / ethyl acetate; ethanol

2: EDC,HOBT / dimethylformamide / 0 °C

3: Ph₃P / tetrahydrofuran; H₂O / 23 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00582-5