Technology Process of 3-carbomethoxy-6,7-dimethoxy-1-(1,2-cis)-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-(2,3-cis)-2-carboxylic acid
There total 8 articles about 3-carbomethoxy-6,7-dimethoxy-1-(1,2-cis)-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-(2,3-cis)-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
acetic acid; ethyl acetate;
for 24h;
under 760 Torr;
Ambient temperature;
DOI:10.1021/jo00067a057
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) n-BuLi / 1) THF, -78 deg C, 1 min, 2) a) -78 deg C, 1 h, b) room temperature, 50 min
2: SO2, pyridine / benzene / 6 h / Irradiation
3: 44 percent / ZnO / toluene / 0.17 h / Heating
4: 97 percent / NaOMe / methanol / 24 h / Ambient temperature
5: 86 percent / H2 / 5percent Pd/C / ethyl acetate; acetic acid / 24 h / 760 Torr / Ambient temperature
With
pyridine; n-butyllithium; sulfur dioxide; hydrogen; sodium methylate; zinc(II) oxide;
palladium on activated charcoal;
In
methanol; acetic acid; ethyl acetate; toluene; benzene;
DOI:10.1021/jo00067a057
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) n-BuLi / 1) THF, -78 deg C, 5 min, 2) THF, a) -78 deg C to room temperature, b) 17 h
2: 73 percent / trifluoroacetic acid, NaBH4 / acetic acid; CH2Cl2 / 0.1 h / 0 °C
3: 1) n-BuLi / 1) THF, -78 deg C, 1 min, 2) a) -78 deg C, 1 h, b) room temperature, 50 min
4: SO2, pyridine / benzene / 6 h / Irradiation
5: 44 percent / ZnO / toluene / 0.17 h / Heating
6: 97 percent / NaOMe / methanol / 24 h / Ambient temperature
7: 86 percent / H2 / 5percent Pd/C / ethyl acetate; acetic acid / 24 h / 760 Torr / Ambient temperature
With
pyridine; sodium tetrahydroborate; n-butyllithium; sulfur dioxide; hydrogen; sodium methylate; trifluoroacetic acid; zinc(II) oxide;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid; ethyl acetate; toluene; benzene;
DOI:10.1021/jo00067a057
