2898-57-9

Upstream product

• 2859-78-1 4-Bromoveratrole 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 91-16-7 1,2-dimethoxybenzene 
• 2898-56-8 (2-bromo-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone 
• 93-07-2 Veratric acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 149143-83-9 α-(3,4-dimethoxyphenyl)-6-bromoveratryl alcohol 

Downstream Products

• 103477-60-7 1-(3,4-dimethoxyphenyl)-3-hydroxy-5,6-dimethoxy-1,3-dihydrobenzothiophene 2,2-dioxide 
• 149143-88-4 (1S,2S,3S)-1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 149143-84-0 (1S,2S,3R,4S)-1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid bis-((R)-methoxycarbonyl-phenyl-methyl) ester 
• 150132-92-6 (+)-picrodimethylretrodendrin 
• 150132-93-7 (+)-isodimethylretrodendrin 
• 149143-85-1 (1S,2S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-1,2-dihydro-naphthalene-2,3-dicarboxylic acid 3-methyl ester 
• 149143-87-3 3-carbomethoxy-6,7-dimethoxy-1-(1,2-cis)-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-(2,3-trans)-2-carboxylic acid 
• 149143-86-2 3-carbomethoxy-6,7-dimethoxy-1-(1,2-cis)-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-(2,3-cis)-2-carboxylic acid 
• 4718-24-5 (-)-(1S,2R,3R)-1-(3',4'-dimethoxyphenyl)-3-(hydroxymethyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid lactone 
• 1130428-28-2 2-bromo-3',4,4',5'-tetrahydroxydiphenylmethane 
• 1383536-05-7 4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-(2-bromo-4,5-dihydroxybenzyl)benzene-1,2-diol 
• 1383536-04-6 1-(2-(2-bromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzyl)-2,3-dibromo-4,5-dimethoxybenzene 
• 103477-59-4 6-(3,4-dimethoxybenzyl)veratraldehyde 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of bromophenol derivatives as protein tyrosine phosphatase 1B inhibitors

3-Bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (BDB) is a bromophenol purified from the marine red alga Rhodomela confervoides and exhibits potent protein tyrosine phosphatase 1B (PTP1B) inhibition (IC 50 = 1.7 μmol/L). In an effort to improve the PTP1B inhibitory activity, a series of derivatives were designed, synthesized, and evaluated in vitro. The preliminary structure-activity relationship indicated that the tricyclic scaffold and multi-bromine atoms (four to five) attached to the aryl rings are important for PTP1B inhibition. Among these, compound 26 exhibited remarkable inhibitory activity against PTP1B with an IC50 of 0.89 μmol/L, which was approximately two-fold more potent than the initial lead compound BDB.

COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.

Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties

A series of bromophenol derivatives were synthesized and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors in vitro and in vivo based on bromophenol 4e (IC50 = 2.42 μmol/L), which was isolated from red algae Rhodomela confervoides

A General Asymmetric Synthesis of (-)-α-Dimethylretrodendrin and Its Diastereomers

A Diels-Alder cycloaddition between the fumarate of methyl (R)-mandelate 14 and α-hydroxy-α'-aryl-o-quinodimethane 12 produced an exo cycloadduct 15 in 44percent yield which was converted to optically pure (-)-α-dimethylretrodendrin (21) and three of its