-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Base Information

Chemical Name:-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol
CAS No.:145668-33-3
Molecular Formula:C₁₈H₃₄O₂Si
Molecular Weight:310.552
Hs Code.:

<R-(R*)>-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Synonyms:-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Suppliers and Price of -4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of -4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of -4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

There total 5 articles about -4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 145668-31-1
-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

: 145668-33-3
-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Guidance literature:: With potassium carbonate; In methanol; for 2.5h;
DOI:10.1021/jo00056a013

Reference yield:

: 18173-64-3
tert-butyldimethylsilanol

: 145668-33-3
-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, r.t., 30 min, 2.) 55-60 deg C, 23 h

2: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

3: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

4: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

5: 91 percent / K₂CO₃ / methanol / 2.5 h

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00056a013

Reference yield:

: 145668-28-6
2-(tert-butyldimethylsilyloxy)methyl-3-chloroprop-1-ene

: 145668-33-3
-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(4-methylcyclohexen-1-yl)-3-methylene-2-butanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

2: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

3: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

4: 91 percent / K₂CO₃ / methanol / 2.5 h

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00056a013