Technology Process of (S)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2H-pyran-4(3H)-one
There total 1 articles about (S)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2H-pyran-4(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde;
With
(1R,2S) Jacobsen's chromium catalyst; barium(II) oxide;
In
ethyl acetate;
at 0 - 20 ℃;
Inert atmosphere;
danishefsky's diene;
In
ethyl acetate;
at 0 - 4 ℃;
Darkness;
Inert atmosphere;
With
trifluoroacetic acid;
In
ethyl acetate;
at 0 - 20 ℃;
optical yield given as %de;
Inert atmosphere;
DOI:10.1021/ol802942j
- Guidance literature:
-
bromostyrene;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
dimethyl zinc(II);
In
tetrahydrofuran; toluene; pentane;
at -78 - 0 ℃;
Inert atmosphere;
(S)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2H-pyran-4(3H)-one; methyl iodide;
Further stages;
DOI:10.1021/ol802942j
- Guidance literature:
-
bromostyrene;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
dimethyl zinc(II);
In
tetrahydrofuran; toluene; pentane;
at -78 - 0 ℃;
Inert atmosphere;
(S)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2H-pyran-4(3H)-one; methyl iodide;
Further stages;
DOI:10.1021/ol802942j
