(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

Base Information

Chemical Name:(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene
CAS No.:634181-94-5
Molecular Formula:C₁₉H₁₆F₂O₄S
Molecular Weight:378.396
Hs Code.:

Synonyms:(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

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Chemical Property of (2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

Chemical Property:

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Technology Process of (2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

There total 1 articles about (2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93-97-0
benzoic acid anhydride

: (3R,5S)-5-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene-3-ol

: 634181-94-5
(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

Guidance literature:: With dmap; triethylamine; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jo034512i

Reference yield:

: 634181-94-5
(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

: 1027046-58-7
C₁₉H₁₆F₂O₅S

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -40 ℃; for 0.666667h;
DOI:10.1021/jo034512i

Reference yield:

: 634181-94-5
(2S,4R)-4-benzoyloxy-2-[(benzoyloxy)methyl]-3,3-difluorotetrahydrothiophene

: C₁₉H₁₄F₂O₄S

Guidance literature:: Multi-step reaction with 2 steps

1.1: m-CPBA / CH₂Cl₂ / 0.67 h / -40 °C

2.1: HMDS; ammonium sulfate / 1,2-dichloro-ethane / Heating

2.2: 36 mg / TMSOTf / 1,2-dichloro-ethane / 0.83 h / 0 °C

With ammonium sulfate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; 1,2-dichloro-ethane; 2.2: Pummerer reaction;
DOI:10.1021/jo034512i