imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

Base Information

Chemical Name:imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide
CAS No.:213664-71-2
Molecular Formula:C₂₅H₂₈N₆O₂S
Molecular Weight:476.602
Hs Code.:

imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>b</i>]azepin-3-yl}-amide

Synonyms:imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

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Chemical Property of imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

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Technology Process of imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

There total 7 articles about imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1877-77-6
3-aminobenzenemethanol

: 213664-71-2
imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / acetonitrile / 3 h / 20 - 50 °C

2: 93 percent / Et₃N / dimethylformamide / 1 h / Ambient temperature

3: 80 percent / LiBr / dimethylformamide / 1.3 h / 0 °C

4: tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

5: H₂ / 10 percent Pd/C / methanol / Ambient temperature

6: acetonitrile / 0.33 h / -50 - 20 °C

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm990044m

Reference yield:

: 97278-68-7,86499-24-3
3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine

: 213664-71-2
imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: acetonitrile / 0.33 h / -50 - 20 °C

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm990044m

Reference yield:

: 211761-74-9
3-(N-(isopropylureido))benzyl bromide

: 213664-71-2
imidazole-1-carbothioic acid {1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: acetonitrile / 0.33 h / -50 - 20 °C

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm990044m